Figure 1. Main readouts for GPCR signaling pathway investigations, including cyclic AMP, IP1, and p-ERK. Advanced Phospho-ERK1/2 Assay. These assay miniaturization and detection issues have led ...

Growth factors trigger G proteins (in green) to disengage from GPCRs and change localization within cells. At right: A ribbon diagram of the G protein structure shows the position of all ...

Omeros Corporation (Nasdaq: OMER) today announced a new approach to cancer immunotherapy that targets inhibition of GPR174, a member of the family of ...

Whereas GPCRs act through intracellular molecular switches (G proteins), growth factor receptors are conventionally thought to bypass the switches. However, Ghosh and Kufareva note that researchers ...

Scientists illuminate mechanism of common drug target Date: April 27, 2022 Source: Columbia University Irving Medical Center Summary: Using advanced imaging methods, researchers have gained ...

The GPCRs, which were first theorized and discovered at Duke by the study's senior author, Robert J. Lefokowitz, MD, begin a signaling cascade that transmits a message from the cell surface, such ...