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Novel AI method sheds light on how enzyme linked to Alzheimer's selects its targets
Researchers from DZNE, Ludwig-Maximilians-Universität München (LMU), and Technical University of Munich (TUM) have found that ...
IEEE21h
Machine Learning to Support the Presentation of Complex Pathway Graphs - IEEE Xplore
Visualization of biological mechanisms by means of pathway graphs is necessary to better understand the often complex underlying system. Manual layout of such pathways or maps of knowledge is a ...
Study traces evolutionary origins of essential PRPS enzyme complex
University of Cincinnati Cancer Center researchers looked billions of years into the past to learn more about the potential ...
IEEE3d
Motif-Aware Adversarial Graph Representation Learning
Graph representation learning has been extensively studied in recent years. It has been proven effective in network analysis and mining tasks such as node classification and link prediction. Learning ...
C&EN8d
On the Origins of Enzymes: Phosphate-Binding Polypeptides Mediate Phosphoryl Transfer to Synthesize Adenosine Triphosphate - ACS Publications
Reactions involving the transfer of a phosphoryl (−PO32–) group are fundamental to cellular metabolism. These reactions are catalyzed by enzymes, often large and complex, belonging to the ...
C&EN8d
Processing Mechanism and Substrate Selectivity of the Core NuA4 Histone Acetyltransferase Complex | Biochemistry - ACS Publications
Esa1, an essential MYST histone acetyltransferase found in the yeast piccolo NuA4 complex (picNuA4), is responsible for genome-wide histone H4 and histone H2A acetylation. picNuA4 uniquely catalyzes ...