The trimeric Rrp4 cap structure increases the catalytic efficiency of the enzyme complex 7,16 and provides substrate specificity for polyadenine (poly(A)) or adenine-rich stretches of RNA 8,16.

Research on γ-secretase reveals its unique substrate recognition mechanism, offering potential for developing precise ...

The Enzyme-Substrate Complex. The fleeting union of the enzyme and the substance on which it acts holds a key to our understanding of life processes.

Overview of Enzyme Kinetics. When an enzyme (E) interacts with its substrate (S), an enzyme-substrate complex (ES) is formed. This complex is converted to its transition state (ES*), then enzyme ...

Enzymes can discriminate between very closely related molecules; three structural determination methods, the enzyme-substrate complex, and its analog can be directly observed.

Scientists crack structure of enzyme complex linked to cancer ... important information for understanding de novo DNA methlylation. A substrate is a material or substance on which an enzyme acts.

Scientists crack structure of enzyme complex linked to cancer. ScienceDaily . Retrieved June 2, 2025 from www.sciencedaily.com / releases / 2018 / 02 / 180207140404.htm ...

High-resolution cryo-electron microscopy makes it possible to study complex enzymatic processes in detail. With this method, ...

Led by first author Bibek R. Karki and senior author Tom Cunningham, the research, published in the journal Nature ...

Interestingly, the sugar-cleaving enzyme was detected in the cell nucleus, while the substrate is thought to be located in the vacuole. After the sugar has been cleaved, the substances are highly ...