Enzyme mechanisms are the chemical transformations, and the steps within them, generated by enzymatic action on substrates. The mechanism of enzyme catalysis is similar in principle to other types ...

Generations of students have been introduced to this subject with the first and second editions of Enzyme structure and mechanism by Alan Fersht. The detailed introductory descriptions of stopped ...

Northwestern Medicine investigators have discovered a novel mechanism that recognizes and eliminates "bad" transcriptional elongation enzymes during gene expression, findings that may inform the ...

Instead of the enzyme mechanism described in biochemistry text-books, hen lysozyme hydrolysis was postulated to occur by a ring-opening mechanism based on substrate interactions defined by the active ...

Male ruffs have the ability to eliminate excess sex hormones from their bloodstream. We often associate high testosterone ...

Lung cancer is a particularly challenging form of cancer. It often strikes unexpectedly and aggressively with little warning, and it can shapeshift in unpredictable ways to evade treatment.

Uncovering similar mechanisms in other organisms could inspire new strategies to target diseases linked to transcription-related genome instability. "We predict that other enzymes likely serve ...

(b. 1964) B.S., 1986, University of Massachusetts, Amherst; Ph.D., 1991, Brown University; National Institutes of Health Postdoctoral Fellow, 1991 – 1994 ...

“It was quite a surprise that this sensor turned out to be an enzyme,” said Chen. “[However], it became very clear after we discovered cGAS [that] it was a very simple and clear mechanism of action.” ...

The research sheds new light on how this enzyme influences glucagon secretion ... Dr. Kaestner added, "This research uncovers a critical mechanism that helps maintain blood sugar balance, moving ...

Get Instant Summarized Text (Gist) A novel mechanism has been identified that eliminates defective transcriptional elongation enzymes during gene expression. This process involves the ARMC5 ...