In this Review, familial and sporadic neurological disorders reported to have an etiological link with DNA repair defects are discussed, with special emphasis placed on the molecular link between ...

Single-strand breaks generated during DNA repair were observed converting to double-strand breaks and reversibly switching between states in response to oxidation in cultured neurons as well as in ...

Aluminum stress is an important factor limiting plant growth in acidic soil, and has significant effects on the growth, development and physiological metabolism of Mentha canadensis. However, the ...

Homologous recombination is a DNA repair mechanism that allows cells to correct double-strand breaks, one of the most severe types of damage. This process uses a similar DNA sequence as a template to ...

Advances in CRISPR technologies promise to accelerate the burgeoning pipeline of gene-editing therapies and broaden access to these disease-altering therapies.

In a Phase I/II trial, patients with X-linked chronic granulomatous disease will receive a treatment created using a new ...

People genetically susceptible to Huntington's disease often see their movement, mood, and cognition decline slowly over time.

That information exists in a code — deoxyribonucleic acid (DNA) — the blueprint for life. That code is stored in dense, coiled structures called chromosomes. A single strand of DNA within a ...

How cells respond to mitochondrial DNA (mtDNA) damage is not fully understood. This study uncovers a mechanism of mtDNA ...