Your DNA is continually damaged by sources both inside and outside your body. One especially severe form of damage called a ...

DNA Repair Proteins Monitored At Double-strand Break Date: May 10, 2007 Source: St. Jude Children's Research Hospital Summary: Scientists had a molecule's eye view of the human cell's DNA repair ...

The newly synthesized DNA (light blue) can then be joined with the 5' end of the resected strand, forming a double Holliday junction (double-strand break repair; DSBR), or can be displaced and ...

DNA double-strand breaks (DSBs) are critical lesions that can result in cell death or a wide variety of genetic alterations including large- or small-scale deletions, loss of heterozygosity ...

Recent efforts in our lab have focused on complexes mediating DNA double strand break (DSB) repair. These range from the Structure Maintenance of Chromosome Smc5/6 complex involved in rescue of ...

Studies in the field of DNA repair usually tend to look at simpler versions of double-strand breaks, he said. Dr. Daley found that each resection enzyme is tailored to deal with a specific type of ...

DNA damage has been associated with aging and disease. Double-strand breaks are one of the worst forms of damage. New research shines a light on the repair process.

A new research paper was published in Aging's Volume 15, Issue 19, entitled, “Reduction of double-strand DNA break repair exacerbates vascular aging.” ...

A new study in Nature Plants reveals that DNA double-strand break repair (DSBR) pathways help prevent gene transfer from organelles to the nucleus in plants. Disruption of DSBR increases the risk ...

Researchers from Osaka University have found that protein phosphatase 1 binds to RIF1 at double-strand DNA breaks to promote repair by the non-homologous end joining pathway instead of the ...

Researchers from Tokyo Metropolitan University have been studying DNA repair by homologous recombination, where the RecA protein repairs breaks in double-stranded DNA by incorporating a dangling ...

High-resolution cryo-electron microscopy has revealed the structural mechanism by which human RAD51 mediates strand exchange during homologous recombination, a key DNA repair pathway.