DNA makes RNA, RNA makes protein, protein makes phenotype—was the guiding framework for understanding inheritance and disease. This model explained classic Mendelian traits, such as how single DNA ...

How does a cell know when it’s been damaged? A molecular alarm, set off by mutated RNA and colliding ribosomes, signals ...

Cells primarily repair double-strand breaks by either rejoining the broken DNA ends or by using another DNA molecule as a template for repair. However, my team and I discovered that RNA, a type of ...

Cells use a step-by-step process to untie knots in DNA, called G4 structures. First, the G4 knot is recognized as a problem by the cell. Special DNA damage response proteins start the repair by ...

Even after this treatment gained FDA approval for cell-based gene therapies for the treatment of sickle cell disease in 2023, there remain many barriers to commercial access. However, when it delivers ...

Jan. 15, 2025 — While most known types of DNA damage are fixed by our cells' in-house DNA repair mechanisms, some forms of DNA damage evade repair and can persist for many years, new research shows.

In 1978 researchers developed a DNA-based diagnostic for sickle cell. In 1984 a child with leukemia—who also had sickle cell—was given a bone marrow and blood transplant.

Innovations in cell-free gene synthesis decrease turnaround times for obtaining full-length, complex, NGS-verified DNA from weeks or months to as few as 6-8 business days. Cell-free DNA speeds ...

Sunburn has traditionally been attributed to UV-induced DNA damage. However, a new study reveals that RNA, another vital cellular molecule, plays a major role in triggering acute sunburn reactions.

Additionally, we found that RNA aids in double-strand break repair in both yeast and human cells, suggesting that its role in DNA repair is evolutionary conserved across species.