A predictive biophysical model that integrates protein-DNA structures and sequences to accurately determine genomic binding sites and affinities of DNA-binding proteins.

Nonspecific major groove DNA-binding domains from both monomers embrace the DNA in a clamp-like structure. The interleaved nucleotide-binding sites are located far from the DNA.

In biology textbooks and beyond, the human genome and DNA therein typically are taught in only one dimension. While it can be ...

This study reports the important development and characterization of next-generation analogs of the molecule AA263, which was previously identified for its ability to promote adaptive ER proteostasis ...

A photoswitchable, DNA structure-specific small-molecule probe, named G4switch, has been developed for the reversible targeting of DNA G-quadruplexes (G4s) in vitro and within cells.