DNA methylation and histone modification influence each other during development. Histone methylation can help to direct DNA methylation patterns, and DNA methylation seems to serve as a template ...

Hepatocellular carcinoma (HCC) is the most common primary liver cancer and a leading cause of cancer-related deaths worldwide ...

A study links the loss of DNA methylation across the genome—as is common in cancer—to the disruption of the 3-D compartments that organize the genome and to the timing of DNA replication.

The accurate distribution of chromosomes in an oocyte is essential for the correct transmission of genetic information to the ...

Mol. Cell 82, 1186-1198. Crosstalk Between Histone and DNA Marks Both histone modification and DNA methylation contribute to the establishment of patterns of gene repression during development, ...

It's widely accepted that molecular mechanisms mediating epigenetics include DNA methylation and histone modifications, but a team from Thomas Jefferson University has evidence to the contrary ...

Aging involves complex cellular and molecular changes, including epigenetic modifications like Deoxyribonucleic acid (DNA) methylation and histone marks. Age predictors, or "clocks," have been ...

DNA and RNA methylation, initially thought to operate as distinct pathways, have been shown to interact closely, shifting our understanding of gene regulation. A team of researchers from the ...

Modification of histone tails, by acetylation, methylation or phosphorylation, affects the local chromatin structure and the transcriptional regulation of adjacent genes. Pericentric heterochromatin ...

This modification, outlined in a paper published in Neuron, is the mono-methylation ... whether histone post-translational modifications, essential proteins that dictate DNA availability and ...