ATM and ATR as sensors of DNA damage: variations on a theme? Curr Opin Cell Biol 13, 225–231 (2001). Hartwell, L. H. & Weinert, T. A. Checkpoints: controls that ensure the order of cell cycle ...

Another important checkpoint takes place later in the cell cycle, just before a cell moves from G 2 to mitosis. Here, a number of proteins scrutinize the cell's DNA, making sure it is structurally ...

The S phase checkpoint is a kinase signaling cascade that is activated in response to DNA damage or fork stalling during replication ... fork blocks before entry into mitosis by inducing cell cycle ...

While lower levels of hydrogen peroxide produced by DAAO at the mitochondrial membrane did not damage DNA or pause the cell cycle, higher concentrations reduced cells’ viability. The researchers ...

How cells respond to mitochondrial DNA (mtDNA) damage is not fully understood. This study uncovers a mechanism of mtDNA ...

Most dividing cells in the body have well-defined checkpoint mechanisms to sense and correct DNA damage during DNA replication. Neurons, however, do not divide. For this reason, they are at ...

or aberrant DNA damage checkpoints. Although replication stress can lead to DNA damage, cell cycle arrest, interferon (IFN) signaling, and senescence or cell death, some cancer cells can evolve to ...

DNA repair systems recognize it as DNA damage and trigger a form of permanent cell cycle arrest called replicative senescence, which may lead to cell death called apoptosis. 5 This checkpoint is ...

WEE1 acts as a master regulator of the G1-S and G2-M cell cycle checkpoints ... DNA. By inhibiting WEE1, azenosertib enables cell cycle progression, despite high levels of DNA damage, thereby ...

They investigated whether allografts are sensitive to immune checkpoint blockade ... To determine whether the cell cycle synthesis (S)-phase-specific DNA damage caused by CDK12 loss is associated ...

Marks Chair in Molecular Cell Biology Scientists know that ... In identifying proteins critical to DNA repair, molecular biologist John Petrini may expand knowledge of how unrepaired DNA damage can ...