The cancer drugs called PARP inhibitors have a puzzling reputation: even though they are treatment mainstays for multiple ...

Cancer cells mount an instant, energy‑rich response to being physically squeezed, according to a study published in the journal Nature Communications. The surge of energy is the first reported ...

New research shows how cells carrying damaged DNA can sidestep cell cycle checkpoints that should prevent them from dividing in a damaged state.

Conserved checkpoints delay cell cycle progression or promote cell cycle exit in response to DNA damage, thus preventing genome instability and aneuploidies commonly associated with cancers (Matthews ...

A new stem cell therapy has repaired blinding damage to the cornea in 93% of patients in an early clinical trial. However, severe injuries, such as those caused by chemical burns or infections ...

The bioaccumulation and persistence of glyphosate within bones impacts stem cells and heightens the risk of blood cancers.

Synopsis How cells respond to mitochondrial DNA (mtDNA) damage is not fully understood. This study uncovers a mechanism of mtDNA clearance following damage, driven by the exonuclease activity of the ...

Cell crowding in NIH3T3 cells induced reinforcement of actin filament structures, cell stiffening, and nuclear downsizing, resulting in a significant decrease in endogenous DNA damage, whereas cell ...

More specifically, high-pORG and liver metastatic primary tumor cells can develop tolerance to ongoing replication stress by increasing cell cycle activity and DNA damage repair processes.