The identification of promising lead compounds from high-throughput screens is still a very complex problem. A new high-throughput assay for identifying aggregation-based false positives could help.

If an object that's composed of two types of material is going to fail, the break will usually occur at the interface where ...

Inspired by how nature blends toughness and flexibility, such as the rigid structure of bone surrounded by pliable cartilage, ...

Methods based on 3D Gaussian Splatting (3DGS) for surface reconstruction face challenges when applied to large-scale scenes captured by UAV. Because the number of 3D Gaussians increases dramatically, ...

Could a legendary tomb curse become a medical miracle? Scientists may have reengineered Aspergillus flavus, linked to King ...

A study revealed carnosic acid in herbs may help combat Alzheimer's by reducing inflammation and improving brain cell ...

ProtoBind-Diff was developed as a foundational component of Gero’s generative drug discovery platform. The model leverages pre-trained protein embeddings (ESM-2) and a denoising diffusion framework to ...

This article explores how generative chemistry accelerates drug design, identifies novel compounds and complements ...

The team says that the cost remains minimal since only a tiny amount of GaN material is added to the chip, but the resulting device can receive a significant performance boost from compact, high-speed ...

Biophotonic technologies such as Raman spectroscopy are powerful tools for obtaining highly specific molecular information. Due to its minimal sample preparation requirements, Raman spectroscopy is ...

Succinate dehydrogenase (SDH) is an ideal fungicidal target. Here, a three-dimensional quantitative structure–activity relationship (3D-QSAR) was established based on the data of 74 compounds with ...

Enter the press: 3D Printed dies rest inside a spring-loaded housing, performing the required bends. Indeed, they were able to improve the shape of the design thanks to the precision afforded by ...