Organizing data in a specific order, also known as sorting, is a central computing operation performed by a wide range of ...

Age-related macular degeneration (AMD) remains a leading cause of vision loss, but new therapies are reshaping its treatment.

Our data indicate that blocking the complement system exacerbates LCWE-induced KD vasculitis, potentially by impairing C3-mediated clearance of bacterial components. Our studies reveal the ...

This systematic review comprehensively summarizes treatment approaches for all types of age-related macular degeneration (AMD ...

ARO-C3 is an investigational RNA interference therapeutic designed to reduce liver production of complement component 3 as a potential therapy for various complement-mediated diseases.

The C-terminal fragment functions as a cysteine protease with a unique proteolytic activity and structure, which degrades several components of the complement system, such as C3 and C3b. Murine ...

Key Points 1. The complement system is involved in several renal diseases. In some disease it is involved deeply, and in such diseases the treatment is principally based on anti-complement drugs. In ...

The Complement System The complement system is an evolutionarily conserved central player in humoral innate immunity.