Clinical notes ... to ensure the inclusion of all studies on online medical information sharing. The full search strategy can be found in online supplemental appendix 1. The review included randomised ...

Abstract Results of subgroup analysis (SA) reported in randomized clinical trials (RCT) cannot be adequately interpreted without information about the methods used in the study design and the data ...

Objective To document clinical trial data flow in global clinical trials published in major journals between 2013 and 2021 from Global South to Global North. Design Scoping analysis Methods We ...

Introduction This study protocol describes a trial designed to investigate whether high-flow heated and humidified nasal oxygen (HFHO) therapy in patients with hypercapnic acute respiratory failure ...

Background Well designed and properly executed randomised trials are considered the most reliable evidence on the benefits of healthcare interventions. However, there is overwhelming evidence that the ...

Transparent, well-designed clinical trials are a must. FastWave Medical's Scott Nelson has advice on how to get there.

Clinical outcomes and cost-effectiveness of fractional flow reserve-guided percutaneous coronary intervention in patients with stable coronary artery disease: three-year follow-up of the fame 2 trial ...

The effect of temporary blood flow arrest during endovascular thrombectomy for acute ischemic stroke is uncertain due to the lack of evidence from randomized controlled trials. We aimed to investigate ...

Clinical trial design development is aided by master protocols, which include sub-studies including umbrella studies, basket studies, platform studies, and master observational trials.

| Now’s the time to rethink clinical trials with real-world data (RWD). Discover strategies to optimize your protocols and site selection.

Increasing the use of community-based trials requires updating the regulatory framework that governs innovative clinical trial designs.