Immune checkpoints are regulatory proteins that prevent the immune system from attacking healthy tissues. Some cancer cells ...

Researchers at Washington University School of Medicine in St. Louis have revealed the structure of a key protein involved in ...

A research team led by Professor Takuya Yamamoto (Department of Life Science Frontiers) and Professor Yasuhiro Yamada at the University of Tokyo has developed a novel in vivo system that reveals how ...

The update strengthens IBTROZI's position as a next-generation treatment in a rare, aggressive lung cancer that often spreads ...

Fibrolamellar hepatocellular carcinoma (FLC) has no approved treatment and occurs mostly in adolescents and young adults - KUALA LUMPUR, Malaysia, July 07, 2025 (GLOBE NEWSWIRE) -- Cyclacel ...

Your morning coffee may offer more than just a quick jolt of alertness. New research from Queen Mary University of London reveals caffeine's remarkable ability to extend the lifespan of cells by ...

DNA damage activates the DNA damage response (DDR) and cell cycle checkpoint signaling, which retards cell cycle progression to ensure sufficient time to repair DNA damage.

Loss-of-function variants in genes encoding tumor suppressor proteins, such as those that mediate DNA repair and cell-cycle checkpoints, can also contribute to an unstable genome.

About 100 cells divide every second in our body. A key protein in cell division is a protein kinase termed Plk1, because it activates other proteins involved in this process. Plk1 is also ...

YAP activation induces adult cardiomyocyte division by promoting cytoskeleton disassembly and mitotic rounding. Adult cardiomyocytes enter the cell cycle at the G1-S transition and progress through ...

Studies have shown that such pathogenesis is related to abnormal cell cycle progression. The expression levels of cyclins, cyclin-dependent kinases (CDKs), and CDK inhibitors as well as functions of ...