Leukocyte and endothelial adhesion molecules play key roles in the development and progression of atherosclerosis. In animal models, blocking or eliminating P-selectin, VCAM-1 or α 4 β 1 integrin ...

When you blow out your birthday candles each year, you’re marking the passage of time but not necessarily the passage of age.

In urodele amphibians, an early step in limb regeneration is skeletal muscle fiber dedifferentiation into a cellulate that proliferates to contribute new limb tissue. However, mammalian muscle cannot ...

Here we use cryogenic electron microscopy to determine the structure of TbAQP2 from Trypanosoma brucei, bound to either the substrate glycerol or to the sleeping sickness drugs, pentamidine or ...

A study published in mBio details the vulnerability of coronaviruses to inhibitors of a small protein domain called Mac1, or the "macrodomain," found in all coronaviruses such as SARS-CoV-2 and ...

During the 3-D ICs manufacturing process, TSVs are susceptible to undergo different faults. Among these faults, the leakage fault is one of the most common cases. In this paper, a new test structure ...

The classical model for DNA groove binding states that groove binding molecules should adopt a crescent shape that closely matches the helical groove of DNA. Here, we present a new design strategy ...

In the future, it may be possible to produce bioactive molecules and pharmaceuticals without reverting to using enzymes or metals as external catalysts. Chemists at Friedrich-Alexander ...

New World Development Co., the distressed Hong Kong developer that’s unsettled investors by delaying some debt payments, faces a critical test Monday when interest comes due on a dollar bond.