ALK-positive anaplastic large-cell lymphoma (ALCL) represents approximately 3% of non-Hodgkin's lymphomas in adults and 10–30% of paediatric lymphomas. 5 It is a T-cell-derived neoplasm ...

Hierarchical clustering of peripheral T-cell lymphomas not otherwise specified (PTCL-NOS), angioimmunoblastic lymphoma (AILT), normal T cells, and anaplastic large-cell lymphoma (ALCL) samples ...

Anaplastic large-cell lymphoma (ALCL), as defined in the World Health Organization, is a heterogeneous category in which a subset of cases is associated with the t(2;5)(p23;q35) or variant ...

"This is the first core regulatory circuit, to our knowledge, identified for ALCL," Abraham said. Of the two major known molecular ALCL subtypes, anaplastic lymphoma kinase (ALK)-positive has an ...

Crizotinib, an inhibitor of the anaplastic lymphoma kinase (ALK) tyrosine kinase, is active in non–small-cell lung cancers that have ALK expression. 1 ALK is fused to several partner genes ...

Anaplastic large-cell lymphoma (ALCL) is a rare type of cancer of white blood cells. ... called ALK. ALK-positive cancers are more common in young people and usually respond well to chemotherapy.

Anaplastic Large-Cell Lymphoma treatment may involve chemotherapy, targeted therapy, or surgery, depending on the ALK status and type.Early diagnosis and a tailored treatment plan are vital for ...

XALKORI is indicated for the treatment of pediatric patients 1 year of age and older and young adults with relapsed or refractory, systemic anaplastic large cell lymphoma (ALCL) that is ALK-positive.

Oncogenic fusion genes consisting of EML4 and anaplastic lymphoma kinase (ALK) are present in a subgroup of non–small-cell lung cancers, representing 2 to 7% of such tumors.We explored the ...

The article by Piva et al, entitled, Gene Expression Profiling Uncovers Molecular Classifiers for the Recognition of Anaplastic Large-Cell Lymphoma Within Peripheral T-Cell Neoplasms” (J Clin Oncol 10 ...

Anaplastic large cell lymphoma (ALCL) is a rare subtype of non-Hodgkin lymphoma and a form of T-cell lymphoma. Read about symptoms, diagnosis, and treatment.