Maintaining the balance between ATP production and consumption is essential for cell survival. AMP-activated protein kinase (AMPK) is an energy sensor that, when energy levels are low, stimulates ...

Cell Death & Disease - Bmf upregulation through the AMP-activated protein kinase pathway may protect the brain from seizure-induced cell death Skip to main content Thank you for visiting nature.com.

Through in vivo magnetic resonance spectroscopy, glucose mass spectroscopy, and electroencephalographic and molecular studies, here we show that the energy sensor AMP activated protein kinase ...

Lipid kinases are enzymes that play a critical role in both cell signalling and membrane trafficking by phosphorylating lipid molecules in the body. The inhibition of two of these lipid kinases, ...

Molecular features of biguanides required for targeting of mitochondrial respiratory complex I and activation of AMP-kinase. BMC Biology , 2016; 14 (1) DOI: 10.1186/s12915-016-0287-9 Cite This Page : ...

Inhibition of LKKR2 may rescue neurons that are dying due to a type of Parkinson’s disease that is caused by a single genetic mutation.

KiNet's ability to visualize kinase-substrate interactions within pathways, domain families, and custom protein sets offers researchers a powerful tool for knowledge discovery.

Johannessen CM, Boehm JS, Kim SY, et al. COT drives resistance to RAF inhibition through MAP kinase pathway reactivation. Nature. 2010;468:968-972. Crossref. PubMed. Google Scholar. 13. Montagut C, ...