Nimacimab shows comparable weight loss to monlunabant and tirzepatide alone, and an additive effect in combination with ...

They are integral allosteric membrane proteins comprising five identical or homologous subunits symmetrically arranged around a central ionic channel. The acetylcholine (ACh)-binding sites on the ...

Array Bridge is testing promising drug candidates that can effectively bind and even degrade target proteins, but not via ...

By leveraging Domain’s expertise to address challenging GPCRs, DT-9046 represents a groundbreaking advancement in PAR2 modulation employing a differentiated mechanism of action, targeting an ...

Coulter Partners, the global expert building leadership teams for Health, Science and Technology innovation businesses, ...

Structure-based drug design (SBDD) of allosteric compounds introduces complications compared to their orthosteric counterparts; multiple binding sites of interest are considered, and often allosteric ...

Binding at this site locks the spike in a non-infectious, closed conformation. This site is coupled to functionally important regions, but the effects of glycans on these allosteric effects have not ...

The investigation delves into allosteric modulation within the glycosylated SARS-CoV-2 spike protein, focusing on the fatty acid binding site. This study uncovers intricate networks connecting the ...

This study reveals how SV40 helicase unwinds DNA, highlighting ATP hydrolysis's role in translocation and offering insights into viral replication mechanisms.

Gleevec works by blocking the ATP-binding site of BCR-ABL, preventing leukemia cell growth ... include developing inhibitors that precisely target mutant kinases or allosteric inhibitors – new ...