SMC (structural maintenance of chromosomes) protein complexes are ring-shaped molecular motors essential for genome folding. Despite recent progress, the detailed molecu ...

Small-conductance calcium-activated potassium channel 2 (SK2) serves a variety of biological functions by coupling intracellular calcium dynamics with membrane potential. SK2 modulators are in ...

Researchers at the University of Oxford and Nanyang Technological University, Singapore (NTU Singapore) have uncovered the ...

Researchers at the University of Oxford and Nanyang Technological University, Singapore (NTU Singapore) have uncovered the ...

ALKBH1 is a genomic DNA 6mA demethylase that preferentially removes 6mA in bubbled/bulged DNA and ssDNA, instead of dsDNA.

During DNA replication, the classic double helix can temporarily rearrange into an alternative structure known as a DNA three ...

Researchers at the University of Oxford and Nanyang Technological University, Singapore (NTU Singapore) have uncovered the ...

This study highlights novel genotype-driven metabolic adaptations in PM, laying the groundwork for targeted interventions ...

This study reveals the step-wise establishment of nuclear speckle-associated domains (SPADs) during mouse embryogenesis. Using optimized CUT&Tag, researchers found paternal SPADs dominate pre-ZGA ...

Background Steatotic liver disease-related hepatocellular carcinoma (SLD-HCC), a rising global challenge, is characterised by ...