BRCA2 c-Jun homology region does not bind to JNK1. (a) BRCA2 exon 3 activation domain shows sequence similarity with the JNK-binding site in c-Jun (δ-region).The sequence alignment is shown ...

Instead, activation domains can facilitate binding in the first place, revealing a more dynamic interplay between TF structure, cofactors, and chromatin state. This cooperative binding hints that gene ...