Influential indie rock Alex G's major label debut album is called “Headlights.” Releasing Friday, the album is an ...

GFAP, or glial fibrillary acidic protein, supports star-shaped brain cells called astrocytes that help maintain nerve cell ...

This AI system can analyze up to one million DNA letters at once, predicting how tiny changes in noncoding regions trigger ...

Whole-mount 3D imaging at the cellular scale is a powerful tool for exploring complex processes during morphogenesis. In organoids, it allows examining tissue architecture, cell types, and morphology ...

Molecular glues, tiny molecules that connect one protein to another, are promising targets for pharmaceutical research. By ...

An international research team has deciphered a mechanism of the evolutionary arms race in human cells. The findings provide ...

Here, we demonstrate a structure-based small molecule virtual screening and lead optimization pipeline using a homology model of a difficult-to-drug G-protein-coupled receptor (GPCR) target.

Inwardly rectifying potassium channels are activated by neurotransmitters and hormones 3 as well as other intracellular messengers such as kinases and G proteins (reviewed in ref. 10).

This disruption activated the Usp7/Mdm2/p53 pathway, accelerating cellular senescence and OA A prominent class of drugs used for HIV management may accelerate osteoarthritis development CHENGDU, ...

Protein–protein interactions are no longer considered undruggable because of the conceptual and technical advances that allow inhibitors to be generated using rational design principles and ...

GPCRs (G-protein [guanine nucleotide-binding protein]–coupled receptors) play a central physiological role in the regulation of cardiac function in both health and disease and thus represent one of ...