Tridecanoic acid (C13) is a rare, odd-chain saturated fatty acid produced mainly by gut and rumen microbes, entering ...

The CoA based its decision on the fact that the trial judge had failed to take into account the importance of viewing the trademark from different angles. “I struggle with the Supreme Court’s decision ...

Just six months after a newborn at Children's Hospital of Philadelphia was diagnosed with a rare and life-threatening metabolic disorder, doctors were able to develop a personalized treatment ...

Kaliyah Coa did not drown but did die 'swiftly' due to the effect of being in cold water, according to the initial findings of a coroner's request after the 11-year-old's body was found in London ...

Then, BCKAs undergo irreversible oxidative decarboxylation via the branched-chain α-ketoacid dehydrogenase (BCKDH) complex to form acetyl-CoA or succinyl-CoA, which then enter the TCA cycle to produce ...

The catalytic center contains succinate, Mg 2+, and desulfo-CoA (succinyl-CoA analog). (S) Flag-tagged SUCLG1 and disease-derived mutants (P170R and A209E) were expressed in HEK293T cells. SUCLG1 ...

The study explored the role of succinyl-CoA synthetase (SCS) through a series of experiments involving the construction of plasmids through polymerase chain reaction (PCR) amplification ...

Now, researchers show that a form of the enzyme Mitochondrial Succinyl-CoA Synthetase that produces GTP – a molecule important for cellular energy -- increases in oocytes as they age.

Succinyl-CoA-based energy metabolism dysfunction in chronic heart failure. Proceedings of the National Academy of Sciences, 2022; 119 (41) DOI: 10.1073/pnas.2203628119 ...

For example, the scientists found evidence that succinyl-CoA may also be overconsumed in heart failure-affected mitochondria in order to break down ketones as a source of energy.

To account for oxidative substrate-level phosphorylation in the TCA cycle, the mitochondrial respiration rate was multiplied by the P/O ratio attributable to succinyl CoA synthetase (P/O TCA).