Surface-engineered LNPs, propelled by clinical successes like patisiran and mRNA vaccines, enable targeted nucleic acid delivery via ligands (antibodies, peptides) and conjugation chemistries (click ...

This article highlights the current state of macromolecular gene delivery systems, their applications, and the ongoing ...

Gene therapy has emerged as a revolutionary approach to treating genetic disorders by directly addressing underlying genetic abnormalities. However ...

Antibody–siRNA conjugates (ARCs) are a type of promising drug modalities for cancer therapy. However, initial reports of ARCs present the gene knockdown effect only in limited tissues (e.g., muscles) ...

Bioengineered nanovesicles for efficient siRNA delivery through ligand-receptor-mediated and enzyme-controlled membrane fusion Intracellular siRNA delivery is key for RNAi therapy.

Figure 1. Some nanotechnology-based drug delivery platforms, including a nanocrystal, liposome, polymeric micelle, protein-based nanoparticle, dendrimer, carbon nanotube and polymer–drug conjugate.

Vizient's 2024 survey reveals a sharp rise in drug shortages across US health care, with pediatric care hit especially hard and labor costs soaring—but the true impact may go far beyond limited ...