No longer a mere assistant who carries out the commands of DNA, RNA takes the lead in emerging therapeutics.

To estimate the readthrough efficiency of the AGO1 stop codon, these authors used a dual-luciferase reporter system in which AGO1-F-luc and R-luc were translated from separate mRNAs. AGO1-F-luc ...

Advances in de novo synthesis of DNA and computational gene design methods make possible the customization of genes by direct manipulation of features such as codon bias and mRNA secondary structure.

Professor Hirohide Saito and his research team have developed a new microRNA-responsive hybrid mRNA switch, enabling precise, ...

To overcome the inherent challenge of translation termination interference caused by stop codon reprogramming in mammalian ...

To build proteins, cells rely on a molecule called transfer RNA, or tRNA. tRNAs act like protein-building couriers, where ...

The elephant vaccine closely resembles other mRNA vaccines made for humans. mRNA packed in lipid nanoparticles carries ...

Compared to the standard shot, the mRNA vaccine had an overall vaccine efficacy that was 26.6 percent higher, and 27.4 ...

To overcome the inherent challenge of translation termination interference caused by stop codon reprogramming in mammalian ...

Scientists have discovered the internal shape of tiny drug-delivery particles – called lipid nanoparticles – has a big impact ...