While humans exploit the venom as a psychedelic, it can cause irritation of the eyes and mouth of humans. Possession of the toad's venom is illegal in California, according to the zoo.

The toad, also known as the Colorado River toad, is one of the largest found in North America — measuring nearly 7 inches, according to the park service. It also has a "weak, low-pitched" sound.

Venom from the Sonoran Desert toad contains a psychoactive compound that can be ingested to induce a powerful psychedelic experience. This toxic psychedelic is illegal in the US but is gaining ...

Mike Tyson Smokes Toad Venom — And That’s Just the Beginning The decorated fighter is set to take on Jake Paul in the highly anticipated heavyweight fight on Netflix on Nov. 15. By Shanelle Genai ...

Evidently, toad venom contains other molecules besides 5-MeO-DMT, including a drug called bufotenine (5-HO-DMT), which also has some psychoactive effects, but are far less intense.

“Toad medicine is watching the movie in 3-D,” added Dr. Sandoval, who owns a ranch in Sonora, where he raises the toads and charges $500 for a venom ceremony.

A potential depression treatment might someday come from trip-inducing toad venom. In a new study Wednesday, researchers appear to have deciphered the structural workings of a psychedelic compound ...