Secretory progenitors accumulated αKG, exhibited reduced expression of downstream TCA-cycle enzymes, and showed elevated DNA hydroxymethylation at loci associated with secretory fate.

Working model revealing the role of ALDH4A1 in maintaining an active MPC complex for mitochondrial pyruvate import and TCA cycle entry. Credit: Nature Cell Biology (2025). DOI: 10.1038/s41556-025 ...

The Krebs cycle - the second stage of aerobic cellular respiration The Krebs cycle is the second stage of aerobic respiration and takes place in the mitochondrial matrix . It processes the products of ...

Genome-scale models of metabolism are important tools for metabolic engineering and production strain development. We present an experimentally validated and manually curated model of metabolism in ...

Cyclist John Howes was killed on the dangerous road in 2019 (Image: Oxford Mail) Cyclists, and many others who would like to cycle but are too scared, have campaigned for more than 10 years for a ...

The accounting cycle is an eight-step process that accountants and business owners use to manage a company’s books throughout a particular accounting period—typically throughout the fiscal ...

The Krebs cycle uses about two-thirds of the total oxygen consumed by the body, and generates about ⅔ of the energy. It plays a role in gluconeogenesis, transamination, deamination, and lipogenesis.

The four stages in a butterfly’s life cycle include egg, caterpillar, pupa, and adult. Let’s discuss these in detail below: 1.Egg: A butterfly starts its life as an egg. The female butterfly ...

Once it enters the brain, it can stop the TCA cycle by depleting one of the metabolites, α-ketoglutarate. This means that these brain cells cannot make energy, ultimately leading to their death.

A few months ago I had the equivalent of a science education “mini-rant ” in Forbes. I thought about K-12 class lessons about the water cycle, and the glaring omission in all of them. If you ...