A new tool called PHOTON, developed by scientists at UT Southwestern Medical Center, can identify RNA molecules at their native locations within cells—providing valuable clues to where different RNA ...

New method maps RNA in cells at native locations, revealing spatial responses to signals and offering insight into disease ...

Modifications in proteins after they are synthesized (post-translational) are changes that play a fundamental role in cell ...

We have developed a hidden Markov model and optimization procedure for photon-based single-molecule FRET data, which takes into account the trace-dependent background intensities. This analysis ...

In Biology 101, we learn that RNA is a single, ribbon-like strand of base pairs that is copied from our DNA then read like a recipe to build a protein. But there's more to the story. Some RNA strands ...

By modeling RNA's 3D structure, we can help bridge the gap created by the lack of experimentally determined structures, advancing research on RNA and its crucial roles in life and health.” “It took ...

2018 Structure of the 30 kDa HIV-1 RNA dimerization signal by a hybrid Cryo-EM, NMR, and molecular dynamics approach Structure 26:490–498 Google Scholar; 6. Watts J. M. et al. 2009 Architecture and ...

Researchers led by chemist Claudia Höbartner have now uncovered the 3D structure of the RNA enzyme SAMURI. Their study provides insights into the development of ribozymes and the evolution of ...

Scientists successfully harnessed artificial intelligence (AI) and deep-learning techniques to model atomic-level RNA 3D structures from primary RNA sequences. Called DRfold, this novel AI-based ...

By leveraging RNA foundation models that operate directly at the atomic level with custom data, this AI-driven RNA structure technology can discover novel structural targets across transcripts of ...