The tumor suppressor p53 is a transcription factor that controls the expression of hundreds of genes. Emerging evidence suggests that the p53-induced RNA-binding protein ZMAT3 is a key splicing ...

The NA_mCNN computational method highlights the functional diversity and significance of sodium transporters in membrane proteins using protein language model embeddings (PLMs) and multiple-window ...

Low-density lipoproteins (LDL) - commonly known as bad cholesterol - have long been on scientists' radar as a major contributor to heart disease.

Novel all-in-one computational pipeline identifies protein biomarkers associated with Alzheimer's disease and predicts 3D structural alterations New method offers insights into Alzheimer's ...

Classification of protein sequences into functional and structural families based on machine learning methods is a hot research topic in machine learning and Bioinformatics. In fact, the underlying ...

In a comprehensive review published in MedComm – Future Medicine, researchers elucidate the transformative impact of deep learning technologies on protein structure prediction. This review ...

Scientists at Sanford Burnham Prebys have developed a clearer picture of how crucial machinery in the human cell's recycling process for obsolete and misshapen proteins—known as proteasomes ...

Complementing experimental data from EPR spectroscopy with computational modeling techniques provides access to protein structural dynamics and enables the characterization of rare protein ...

Microsoft has open sourced EvoDiff, an AI system and framework that can generate proteins without needing a protein sequence.

They focused on multi-domain proteins and proposed a strategy to treat the domains as a whole, utilizing XL-MS data between the domains to model the dynamic structures of proteins within cells.

An AI called AlphaFold predicted structures for nearly every protein known to science. Those predictions aren’t without limits, some researchers say.

Google's DeepMind AI Predicts 3D Structure of Nearly Every Protein Known to Science At last, the decades-old protein folding problem may finally be put to rest.