Pediatric Research - Toll-like receptors, the NLRP3 inflammasome, ... the mechanisms by which this single-nucleotide polymorphism, rs10754558, affects NLRP3 function are unknown.

The paper reports a new version of the Cardean CRISPR-Chip called SNP-Chip that can rapidly detect and quantify single nucleotide polymorphisms (SNPs), or point mutations, in unamplified, genomic ...

The human NLR family and inflammasome-associated proteins. There are 22 human NLRs characterized by a central nucleotide-binding domain (NB). The NLR family can be further classified into four ...

Schroder, one of the world’s leading experts in inflammasome biology, has studied NLRP3 for over a decade, and today she directs a center at the University of Queensland dedicated to inflammasomes.

The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease. Nature Medicine , 2015; DOI: 10.1038/nm.3804 Cite This Page : ...

Obesity is known to be associated with metabolic and cardiovascular disorders such as insulin resistance, type 2 diabetes, hypertension, or heart failure, all presenting a chronic low-grade ...

The BioAge family of NLRP3 inhibitors has differentiated features including Unique and novel chemical structures and biological properties Drug-like metabolic stability and potent in vivo activity ...

BioAge identified NLRP3 as a therapeutic target based on analysis of human aging cohorts by the Company’s platform, which revealed that reduced NLRP3 activity is associated with greater longevity.