Multiple myeloma is a malignant disorder characterized by the monoclonal proliferation of plasma cells in the bone marrow. Multiple myeloma and its premalignant state are often detected 1 because they ...

A doctor may also perform a serum protein electrophoresis test to analyze the various proteins in the blood, which can help detect cancerous conditions, including oral cancer.

The gold standard to measure the M-spike protein combines serum protein electrophoresis (SPEP) with immunofixation. 21-23 SPEP separates plasma proteins on the basis of their molecular weight and ...

The tests, serum protein electrophoresis and serum immunofixation electrophoresis, or SPEP/SIFE, and serum free light chain assay, or SFLCA, separate proteins into groups according to their ...