News

C&EN2d
Axial Chirality in the Sotorasib Drug Substance, Part 1: Development of a Classical Resolution to Prepare an Atropisomerically Pure Sotorasib Intermediate | Organic Process ...
Described herein is the discovery and development of a process to prepare an atropisomeric intermediate in the synthesis of the KRAS G12C inhibitor sotorasib. Using high-throughput experimentation, (+ ...
IEEE3d
Development of Flip-Chip Packaging for Monolithic Microwave Integrated Circuit - IEEE Xplore
In this paper, the flip chip joints formed by using gold (Au) stud on commercial-off-the shelf (COTS) monolithic microwave integrate circuit (MMIC) designed for wire bond assembly are evaluated. This ...
C&EN5d
The Whole Is Bigger than the Sum of Its Parts: Drug Transport in the Context of Two Membranes with Active Efflux | Chemical Reviews - ACS Publications
In these analyses, passive diffusion is thought to dominate drug accumulation rates, whereas active transport is expected to numerically offset predictions of the Fick’s laws. (40,55,66,67,70,380,426) ...