Look inside a brain cell with Huntington's disease or ALS and you are likely to find RNA clumped together. These solid-like clusters, thought to be irreversible, can act as sponges that soak up ...

Scientists have created an artificial RNA system that can copy itself using simple building blocks and temperature changes.

The tumor suppressor p53 is a transcription factor that controls the expression of hundreds of genes. Emerging evidence suggests that the p53-induced RNA-binding protein ZMAT3 is a key splicing ...

As the clouds clear on computational crystal structure prediction, is the technique ready to empower mainstream materials research? James Mitchell Crow reports ...

The structure of the Nipah virus polymerase complex elucidated using cryoelectron microscopy.

The crystal structure of the CD-domain alone reveals binding of three Mg ions. Modelling of this domain onto an AlphaFold 3 model of an RNA-L-P complex suggests a catalytic role for one Mg ion in mRNA ...

Study: An update on inhibitors targeting RNA-dependent RNA polymerase for COVID-19 treatment: Promises and challenges. Image Credit: tigerder/Shutterstock RNA-dependent RNA polymerase (RdRp) is a ...

Antiviral drug therapy against SARS-CoV-2 is not yet established and posing a serious global health issue. Remdesivir is the first antiviral compound approved by the US FDA for the SARS-CoV-2 ...

The structure of the SARS-CoV-2 polymerase is at a slightly higher resolution than the SARS-CoV structure and adds some more detail, but the structures are mostly the same.

To find out how the viral RNA polymerase works, the researchers also determined its three-dimensional structure during different transcription steps.

Scientists have recently uncovered the mechanisms of how RNA polymerase II performs intrinsic cleavage reaction to proofread RNA transcriptions, shedding light on how misregulation of accurate ...

Insight into the mechanism of DNA synthesis is provided by the crystal structures of DNA polymerase intermediates.