The researchers found that using a drug to inhibit RNA Polymerase 1 (Pol 1) - the enzyme responsible for human ribosomal RNA (rRNA) transcription - triggered a unique stress response that rewires ...

Researchers at the Johns Hopkins Kimmel Cancer Center and Department of Radiation Oncology and Molecular Radiation Sciences uncovered a new tumor-suppressive response that could lead to novel ...

A new study reveals that blocking ribosomal RNA production rewires cancer cell behavior and could help treat genetically ...

In this Review, te Velthuis and Fodor detail the recently obtained high-resolution structures of the influenza virus RNA polymerase and the insights that have been gained into the mechanisms of ...

RNA polymerase in action. The three stages of transcription involve various functions of RNA polymerase that result in the synthesis of RNA: 1. Initiation begins when RNA polymerase wraps around the ...

Here, a cross-chiral RNA polymerase is developed—an RNA enzyme that can catalyse the templated polymerization of activated mononucleotides that are of the opposite handedness—shedding light on ...

Laiho holds patents on RNA polymerase 1 inhibitors, which are managed by The Johns Hopkins University in accordance with its conflict-of-interest policies. Journal. Cell Chemical Biology.

SAN DIEGO--(BUSINESS WIRE)--TriLink BioTechnologies and Alphazyme, both part of Maravai LifeSciences, have collaborated to launch CleanScribe™ RNA Polymerase, a novel enzyme that reduces double ...

Laiho holds patents on RNA polymerase 1 inhibitors, which are managed by The Johns Hopkins University in accordance with its conflict-of-interest policies. RELATED TOPICS. Health & Medicine.

What am I looking at? This is a 3D rendering of an RNA polymerase II enzyme from baker’s yeast, created using actual molecular data to reconstruct its shape and active sites. What looks like a ...

The RNA-dependent RNA polymerase of the novel coronavirus is a complex that includes the small proteins nsp7 and nsp8. Researchers studying SARS-CoV-2, the novel coronavirus that causes ...

The researchers found that using a drug to inhibit RNA Polymerase 1 (Pol 1) - the enzyme responsible for human ribosomal RNA (rRNA) transcription - triggered a unique stress response that rewires ...