Researchers at the Johns Hopkins Kimmel Cancer Center and Department of Radiation Oncology and Molecular Radiation Sciences uncovered a new tumor-suppressive response that could lead to novel ...

A new study reveals that blocking ribosomal RNA production rewires cancer cell behavior and could help treat genetically ...

The researchers found that using a drug to inhibit RNA Polymerase 1 (Pol 1) - the enzyme responsible for human ribosomal RNA (rRNA) transcription - triggered a unique stress response that rewires ...

Role of RNA polymerase in gene transcription demonstrated Date: July 19, 2010 Source: University of Maryland Summary: Biophysicists have provided new insight into the mechanisms of gene transcription.

Endogenous RNA interference (endo-RNAi) pathways use a variety of mechanisms to generate siRNA and to mediate gene silencing. In Caenorhabditis elegans, DCR-1 is essential for competing RNAi ...

Newly synthesized viral RNA polymerase subunits (polymerase basic 1 (PB1), PB2 and polymerase acidic (PA)) and nucleoprotein (NP) are imported into the nucleus and bind to vRNA genomic segments ...

RNA polymerase in action. The three stages of transcription involve various functions of RNA polymerase that result in the synthesis of RNA: 1. Initiation begins when RNA polymerase wraps around the ...

Laiho holds patents on RNA polymerase 1 inhibitors, which are managed by The Johns Hopkins University in accordance with its conflict-of-interest policies. Journal. Cell Chemical Biology.

The RNA polymerase has two regions in which the lysine residues are arranged in a line. They found that these lysine residues correspond to two of the three paths.

What am I looking at? This is a 3D rendering of an RNA polymerase II enzyme from baker’s yeast, created using actual molecular data to reconstruct its shape and active sites. What looks like a ...

The researchers found that using a drug to inhibit RNA Polymerase 1 (Pol 1) - the enzyme responsible for human ribosomal RNA (rRNA) transcription - triggered a unique stress response that rewires ...

RNA polymerase in action. The three stages of transcription involve various functions of RNA polymerase that result in the synthesis of RNA: 1. Initiation begins when RNA polymerase wraps around the ...