In this model, PKM2 only has the ability to undergo dynamic regulation by FBP (as occurs with bacterial, yeast and liver forms of pyruvate kinase) if a tyrosine kinase pathway is activated.

Calcium pyruvate is a popular supplement often taken in hopes of supporting weight loss goals or improving exercise endurance. This article reviews all you need to know about calcium pyruvate.

The researchers identified the structure of this machine, the mitochondrial pyruvate carrier (MPC), and 50 years since its discovery, have shown how it operates like the lock on a canal to ...

Known as the mitochondrial pyruvate carrier, this molecular machine was first proposed to exist in 1971, but it has taken until now for scientists to visualise its structure at the atomic scale ...

Working model revealing the role of ALDH4A1 in maintaining an active MPC complex for mitochondrial pyruvate import and TCA cycle entry. Credit: Nature Cell Biology (2025). DOI: 10.1038/s41556-025 ...

Pyruvate kinase deficiency symptoms vary from one person to another. The most common symptom is red blood cell breakdown, which causes hemolytic anemia. The signs of this condition include: ...

Min-Oo, G, Fortin, A, Tam, M-F, Gros, P, Stevenson, MM. Phenotypic expression of pyruvate kinase deficiency and protection against malaria in a mouse model. Genes Immun 2004;5:168-175 Crossref ...

Blood lactate and pyruvate levels and lactate-pyruvate ratios were determined in 20 patients with severe hypoxemia due to pulmonary insufficiency, 18 patients having arterial oxygen tensions (pO 2 ...

Exogenous pyruvate plays a pivotal role in maintaining glycolysis–TCA cycle flux and ATP production under high-glucose conditions by suppressing PARP activity.

Known as the mitochondrial pyruvate carrier, this molecular machine was first proposed to exist in 1971, but it has taken until now for scientists to visualise its structure at the atomic scale ...