Researchers studying the energy metabolism of patients with chronic fatigue syndrome have reached the conclusion that these patients have impaired pyruvate dehydrogenase function, but their ...

Will my iPhone get iOS 26? Here’s every supported model We've got the full list of iOS 26 supported devices - find out if you're getting the new iPhone update By John McCann Published June 9 ...

Working model revealing the role of ALDH4A1 in maintaining an active MPC complex for mitochondrial pyruvate import and TCA cycle entry. Credit: Nature Cell Biology (2025). DOI: 10.1038/s41556-025 ...

Pyruvate and related metabolites are linked to reduced glaucoma risk among genetically predisposed individuals and mitigate disease in a mouse model, highlighting a potential metabolic mechanism of ...

The researchers identified the structure of this machine, the mitochondrial pyruvate carrier (MPC), and 50 years since its discovery, have shown how it operates like the lock on a canal to ...

Known as the mitochondrial pyruvate carrier, this molecular machine was first proposed to exist in 1971, but it has taken until now for scientists to visualise its structure at the atomic scale ...

The Food and Drug Administration (FDA) has accepted for Priority Review the New Drug Application for SL1009 (sodium dichloroacetate oral solution) for the treatment of pyruvate dehydrogenase ...

I have recently bought Pyruvate Clacium to try and loose some wait. But for the life of me cannot find a recommended diet or eating plan to use with it. Also, how safe is it if I am trying to fall ...

Paradoxical neuronal hyperexcitability in a mouse model of mitochondrial pyruvate import deficiency Andres De La Rossa Marine H Laporte Simone Astori Thomas Marissal Sylvie Montessuit Preethi ...

Here we evaluate pyruvate as a novel approach in the treatment and prevention of post-TBI depression-like behavior in a rat model. Rats were divided into five groups: (1) sham-operated control with ...