Individual enzymes frequently form a complex with many subunits, as in the case of the pyruvate dehydrogenase complex ... and have also discovered that it functions differently than previously ...

The Food and Drug Administration (FDA) has accepted for Priority Review the New Drug Application for SL1009 (sodium dichloroacetate oral solution) for the treatment of pyruvate dehydrogenase ...

to stimulate residual Pyruvate Dehydrogenase Complex (PDC) activity and increase energy (ATP) production by mitochondria. "This NDA acceptance brings us one step closer to addressing the critical ...

The pyruvate dehydrogenase complex reaction is allosterically inhibited when there are high ratios of ATP to ADP, NADH to NAD + and acetyl-CoA to CoA. Allosteric activation occurs when the ratio ...

Indications: Pyruvate dehydrogenase complex deficiency, typically associated with post-prandial lactic acidemia with a normal lactate/pyruvate ratio, can be assayed in freshly isolated blood ...

Just before she turned one, Harlow was diagnosed with Pyruvate Dehydrogenase Complex Deficiency, commonly called PDCD. In children with PDCD, there is a problem with one of the primary steps that ...

DCA will be used with a proprietary genetic test to treat an orphan pediatric mitochondrial disease, Pyruvate Dehydrogenase Complex Deficiency (PDCD) 1. The FDA granted Priority Review for the NDA ...

DCA is a targeted therapy that inhibits Pyruvate Dehydrogenase Kinase (PDK) to stimulate residual Pyruvate Dehydrogenase Complex (PDC) activity and increase energy (ATP) production by mitochondria.