28.11.2017: Opinions - Researchers studying the energy metabolism of patients with chronic fatigue syndrome have reached the conclusion that these patients have impaired pyruvate dehydrogenase ...

Findings position ALDH4A1 as a structural component of the mitochondrial pyruvate carrier complex, expanding its role beyond proline metabolism to include pyruvate import and TCA cycle entry.

Further experiments confirmed that immunoprecipitated pyruvate dehydrogenase complex subunit E2 showed reduced levels of lipoylation in ECHS1 KO cells, which were again normalized in double KO cells ...

Just before she turned one, Harlow was diagnosed with Pyruvate Dehydrogenase Complex Deficiency, commonly called PDCD.

New research has revealed that birds, reptiles, and mammals have developed complex brain circuits independently, despite sharing a common ancestor. These findings challenge the traditional view of ...

The pallium is the brain region where the neocortex forms in mammals, the part responsible for cognitive and complex functions that most distinguishes humans from other species. The pallium has ...

The FDA has accepted for Priority Review the NDA for SL1009 to treat pyruvate dehydrogenase complex deficiency.

DCA is a targeted therapy that inhibits Pyruvate Dehydrogenase Kinase (PDK) to stimulate residual Pyruvate Dehydrogenase Complex (PDC) activity and increase energy (ATP) production by mitochondria.

DCA is a targeted therapy that inhibits Pyruvate Dehydrogenase Kinase (PDK) to stimulate residual Pyruvate Dehydrogenase Complex (PDC) activity and increase energy (ATP) production by mitochondria.

Saol Therapeutics, a privately held, clinical-stage pharmaceutical company, announced today that the U.S. Food and Drug Administration (FDA) has accepted for review the New Drug Application (NDA) for ...

DCA will be used with a proprietary genetic test to treat an orphan pediatric mitochondrial disease, Pyruvate Dehydrogenase Complex Deficiency (PDCD) 1. The FDA granted Priority Review for the NDA and ...