These cells conceal integrated provirus in a transcriptionally silent state, beyond the reach of both immune surveillance and antiretroviral therapy. Researchers at the Peter Doherty Institute in ...

On its own, knockout of INTS12 increased RNA polymerase II occupancy throughout the provirus region as well as transcription of the full-length HIV provirus. This suggests that INTS12 somehow blocks ...

Cullen and his team found that, in a small number of infected cells, the SMC5/6 protein complex initiates a process that silences the DNA provirus before it integrates into a host cell chromosome ...

The virus persists by integrating its genetic material – or "provirus" – into their genome. This makes it undetectable to the immune system, but also inaccessible to antiretroviral drugs.

Adeno-associated virus 9 targets CD4+ T cells that harbor the latent HIV provirus. Four of the six participant's antiretroviral was interrupted at 12 weeks after the infusion.

For IMG/VR4 we used CheckV to trim out the edges only of the contigs that geNomad had identified as proviruses. If you run genomad find-proviruses -h you can find some extra options that will give you ...

They looked at changes in the detection of the M184V mutation in proviral DNA over time in 22 people with HIV. They looked for provirus containing the M184V mutation in stored blood samples. Samples ...

Overall, HIV-Tocky is a novel tool that captures the kinetics of provirus silencing, a feat not possible with GFP before, allowing for analysis of the complex nature of HIV-1 latency by revealing ...

The human ERV-K exists in the provirus form in the human genome, comprising sequences encoding proteins critical for the reactivation, and RVLP (retrovirus-like particle) formation, having ...

In a study of 10 low-prevalence herds (Table 1), 75 qPCR tests were run on cows that were ELISA-positive. The results showed that 72% of the cows had detectable provirus. Of those cows, 19% had high ...

We looked for sequences that matched each HML-2 provirus in the genome and found 37 different HML-2 proviruses that were still active. All 54 tissue samples we analyzed had some evidence of the ...

Viruses insert their genomes into their hosts in the form of a provirus. There are around 30 different kinds of human endogenous retroviruses in people today, amounting to over 60,000 proviruses in ...