Protein–protein interactions (PPIs) are essential for many biological processes, making them important targets for therapeutic intervention. However, PPIs have proved challenging to target due ...

The ability to alter protein binding can create tailored therapeutics with reduced side effects, sensitive diagnostic tools, targeted drug delivery and sustainable bioremediation. Various approaches ...

In biology, the binding of cellular proteins to molecules called ligands produces a myriad of functions essential for life, including cell signaling and enzymatic action. In biotechnology and medicine ...

Acellera Therapeutics and Psivant Therapeutics announce a strategic research collaboration to develop transformative computation approaches that will accelerate the discovery and optimization of novel ...

EPFL researchers have developed a computational method to explicitly consider the impact of water while designing membrane ...

Researchers have developed a computational method to explicitly consider the impact of water while designing membrane receptors with enhanced stability and signaling, paving the way for novel drug ...

Here we explore peptide inhibitors of Cdc20, a substrate-recognition subunit and activator of the E3 ubiquitin ligase the anaphase promoting complex/cyclosome (APC/C) that is essential in mitosis and ...