Scientists have uncovered how a protein helps build and maintain vital brain connections, providing insights into the ...

The tumor suppressor p53 is a transcription factor that controls the expression of hundreds of genes. Emerging evidence suggests that the p53-induced RNA-binding protein ZMAT3 is a key splicing ...

Next-generation sequencing techniques provide us with an opportunity for generating sequenced proteins and identifying the biological families and functions of these proteins. However, compared with ...

ProtEx builds on traditional protein similarity searches and recent neural models for protein function prediction. Conventional methods, like BLAST, retrieve homologous sequences to infer functions.

A new, AI-based approach has been developed to discover novel deaminase proteins, used in base editing, through structural prediction and classification. The study highlights an approach that uses ...

Journal Cell DOI 10.1016/j.cell.2023.05.041 Article Title Discovery of deaminase functions by structure-based protein clustering Article Publication Date 27-Jun-2023 ...

Gene expression signatures (GES) connect phenotypes to differential messenger RNA (mRNA) expression of genes, providing a powerful approach to define cellular identity, function, and the effects of ...

Structure-based protein classification, compared with sequence-based approach, is able to detect distant relationships, because most protein folds are well-conserved (Tseng and Li, 2012) although ...

A high number of 3TMs have unknown functions and based on this analysis we speculate on the functional involvement of uncharacterized trispanins in relationship to disease or important cellular ...