Medium-chain acyl-CoA dehydrogenase deficiency (MCADD) is a genetic condition that prevents the body from breaking down fat stores for energy. It can be fatal without early diagnosis and treatment.

The substrate of the OGDHC reaction, 2-oxoglutarate, is a precursor for glutamate biosynthesis from glucose. The OGDHC reaction product succinyl-CoA provides for the only mitochondrial phosphorylation ...

Observations made on anesthetized patients with a recently introduced synthetic muscle relaxant, succinylcholine, indicated that this agent, administered in the form of continuous intravenous ...

Figure 1: GlnA 1 -dodecamer-assembly is induced by 2-OG without detectable oligomeric intermediates. Oligomerisation states of purified strep-tagged GlnA 1 were assessed in dependence of 2-OG by mass ...

Scientists have identified a gene that causes production of a substance in some citrus that interferes with many medications.

Successful COA selection matters Selecting the appropriate COA for use in a clinical trial is essential for evaluating the benefits and risks of a treatment and influences how treatment claims are ...

Increased levels of SUCLG1 lead to decreased succinyl-CoA and increased succinate levels. The authors show that this succinyl-CoA decrease reduces succinylation of the mitochondrial polymerase POLRMT ...

Previous studies have demonstrated that the antipsychotic agent, pimozide, can improve hyperglycemia in type 2 diabetes (T2D) secondary to inhibition of the ketone oxidation enzyme, succinyl CoA ...

The E1 component of the 2-oxoglutarate dehydrogenase (Ogdh) complex generates succinyl-CoA from α-ketoglutarate (αKG) in the TCA cycle (see Fig. 3 A). We found that there is a statistically ...