With a straightforward chemical tweak, the addictive—and often deadly—opioid painkiller, fentanyl, may transform into a safe, non-addictive, targeted therapy. Researchers reported this on ...

New synthetic opioid could be 1,000 times more potent than morphine. ... Scientists don’t understand how modifications to their chemical structure will affect their potency, ...

Structure of opioid receptors may reveal how to better design pain relievers, addiction therapies Peer-Reviewed Publication. University of Maryland School of Medicine ...

Knowing how these drugs interact with opioid receptors and having a clear view of this molecular snapshot is critical for allowing researchers to develop more effective pain-relieving drugs.

A study published in the journal Pharmacological Research reveals the oligomeric molecular structure of the MOR-Gal1R complex, a component present in the brain which is involved in the analgesic ...

In the continuing effort to improve upon opioid pain relievers, American and Chinese scientists used cryoEM technology to solve the detailed structures of the entire family of opioid receptors ...

To measure their success, she monitored a molecular signal that diminishes when this type of drug binds. Armed with feedback from these experiments, Gudorf refined the structures she generated. In the ...

Opioids with similar chemical structures can share common epitopes. Epitopes are specific regions on the drug molecule that interact with the immune system.

Brain volume and function are altered in individuals with opioid use disorder, a new Yale study finds. Using magnetic resonance imaging (MRI) and functional MRI (fMRI), researchers observed the ...

INDIANAPOLIS, March 28, 2023 — There’s been a recent push in the U.S. to make naloxone — a fast-acting opioid antidote — available without a prescription. This medication has saved lives, but it’s ...