With a straightforward chemical tweak, the addictive—and often deadly—opioid painkiller, fentanyl, may transform into a safe, non-addictive, targeted therapy. Researchers reported this on ...

New synthetic opioid could be 1,000 times more potent than morphine. ... Scientists don’t understand how modifications to their chemical structure will affect their potency, ...

Neutrally-charged morphine undergoes a chemical reaction in water to become a positively-charged, biochemically active compound. Aaron Harrison, CC BY-ND. This positively charged structure is the ...

Opioids’ molecular magic unmasked. First 3-D views show how drugs bind to cells. Share this: ... A. Manglik et al. Crystal structure of the mu-opioid receptor bound to a morphinan antagonist.

Structure of opioid receptors may reveal how to better design pain relievers, addiction therapies Peer-Reviewed Publication. University of Maryland School of Medicine ...

Brain volume and function are altered in individuals with opioid use disorder, a new Yale study finds. Using magnetic resonance imaging (MRI) and functional MRI (fMRI), researchers observed the ...

Opioids with similar chemical structures can share common epitopes. Epitopes are specific regions on the drug molecule that interact with the immune system.

To measure their success, she monitored a molecular signal that diminishes when this type of drug binds. Armed with feedback from these experiments, Gudorf refined the structures she generated. In the ...

The US Food and Drug Administration (FDA) has issued an urgent warning about tianeptine—a substance marketed as a dietary ...

Knowing how these drugs interact with opioid receptors and having a clear view of this molecular snapshot is critical for allowing researchers to develop more effective pain-relieving drugs.

In the continuing effort to improve upon opioid pain relievers, American and Chinese scientists used cryoEM technology to solve the detailed structures of the entire family of opioid receptors ...

INDIANAPOLIS, March 28, 2023 — There’s been a recent push in the U.S. to make naloxone — a fast-acting opioid antidote — available without a prescription. This medication has saved lives, but it’s ...