The crystal structure of the RCC1–nucleosome core particle shows pseudo-two-fold symmetry: one RCC1 molecule interacts with each of the two histone faces of the nucleosome ().The RCC1 β ...

Scientists have long known that cells in all eukaryotes, from fish to trees to people, pack DNA in exactly the same way. DNA strands are wound around a ‘hockey puck’ composed of eight histone proteins ...

DNA lesions are repaired by a cut-and-remove process called nucleotide excision repair. An in vitro biochemically defined system has been developed in which six repair factors are sufficient to excise ...

Chinese scientists reported the first high-resolution cryo-EM structure of human Polycomb repressive deubiquitinase (PR-DUB) complex bound to the chromatosome particle with mono-ubiquitinated ...

An intermediate chromatin structure during nucleosome remodeling is determined, and may explain how nucleosome repositioning occurs Peer-Reviewed Publication Waseda University ...

A group including Jonathan Widom at Northwestern University and Eran Segal of the Weizman Institute used sophisticated computer modeling along with experimental approaches to uncover DNA-encoded rules ...