Every living cell must interpret its genetic code—a sequence of chemical letters that governs countless cellular functions. A ...

MIT and Recursion have released Boltz-2, the first biomolecular co-folding model that simultaneously predicts molecular structure and binding affinity with remarkable accuracy, approaching that of ...

Structure and function of histone chaperones in replication-coupled chromatin assembly. Curr Opinion in Structural Biol. 2025;92:103059. doi: 10.1016/j.sbi.2025.103059 This article has been ...

Structure content for AI search so it’s easy for LLMs to cite. Use clarity, formatting, and hierarchy to improve your visibility in AI results.

Neuroscientists have produced the largest wiring diagram and functional map of a mammalian brain to date using tissue from a part of a mouse's cerebral cortex involved in vision, an achievement ...

DNA lesions are repaired by a cut-and-remove process called nucleotide excision repair. An in vitro biochemically defined system has been developed in which six repair factors are sufficient to excise ...

Recently, telemedicine solutions have become a new trend in remote medical treatment. Many diseases are originated from abnormal variation of biological processes, especially in nucleosome positioning ...

"Our work suggests that nucleosome structure may impact gene expression in ways that are more complex than we thought", adds Alba Sala, PhD student at IRB Barcelona and first author of the study.

Hibino, K., et al. (2024). Single-nucleosome imaging unveils that condensins and nucleosome–nucleosome interactions differentially constrain chromatin to organize mitotic chromosomes.

Here, we present a cryo-EM analysis of a trimeric complex composed of the nucleosome core particle (NCP), RCC1, and Ran. While the contacts between RCC1 and Ran in the complex are preserved compared ...