Locked nucleic acid (LNA) probes are modified RNA bases where the ribose is locked, thus fixing a specific conformation. They enable shorter probes for qPCR, thereby improving assay sensitivity ...

Modular hybridization probes (M-Probes) have been developed that enable sequence-selective binding of complex nucleic acid targets. The M-probes can target sequences that: are hypervariable at ...

Five years ago, the NCBI Probe database (ProbeDB) was established to provide a centralized archive of molecular probes used in biomedical applications. Currently ProbeDB contains around 10 million ...

First, a peptide nucleic acid (PNA) probe locally opens a chosen target site, which allows a padlock DNA probe to access the site and become ligated. Second, rolling circle amplification ...

SIDEBAR: Selected Suppliers of DNA and RNA Probes In the doctor's office or the research lab, the supreme value of DNA and RNA as diagnostic tools and the high potential of genetic therapy are putting ...

The rapid identification of respiratory virus outbreaks is needed to enable rational and effective public health interventions. We developed new quantitative approaches for simultaneous ...

Nucleic acids may be labeled at their 3’ end, 5’ end, ... it is desirable to generate highly specific probes where the label is distributed throughout the nucleic acid.

A team of researchers have developed an easy-to-use colorimetric assay for the detection of food contaminated with salmonella. The assay is based on a novel nucleic acid probe that is cleaved by ...

When one is detecting nucleic acids by hybridization, there are numerous situations in which it is not desirable to isolate probe-target complexes from the excess of probes that are used. Sanjay Tyagi ...

NUCLEIC ACID AMPLIFICATION AND DETECTION METHODS developed in the past decade are useful for the diagnosis and management of a variety of infectious diseases. The most widely used of these methods is ...

Biotinylated nucleotides have emerged as a powerful tool in molecular biology, enabling researchers to explore genetic materials with unprecedented precision and sensitivity. These modified ...