Brain arteriovenous malformation (BAVM) is an abnormality in the cerebral vascular system. Although the upregulation of the Notch signalling pathway is a deterministic factor in BAVM, the mechanism by ...

The maintenance of proper mitochondrial-associated endoplasmic reticulum membranes is crucial for preventing skeletal muscle atrophy to interact with the Notch signaling pathway.

Reviewer #1 (Public Review): Summary: The Notch signaling pathway plays an important role in many developmental and disease processes. Although well-studied there remain many puzzling aspects. One is ...

In this article, ACROBiosystems discusses the importance of DLL3 and Notch as therapeutic targets for small cell lung cancer treatment.

The Notch pathway is remarkably simple without the interventions of secondary messengers. It possesses a unique receptor–ligand interaction that imparts signaling upon cleavage of the receptor ...

Nevertheless, the underlying mechanism of RASSF1A‐dependent tumor dedifferentiation remains elusive. Here, we show that RASSF1A directly uncouples the NOTCH‐HES1 axis, a key suppressor of ...

Growing studies have shown Notch signaling pathway plays a pivotal role in the regulation of NAFLD progression. Here, we review the profile of the Notch signaling pathway, new evidence of Notch ...

Notch signaling pathway. Image Credit: Ellepigrafica / Shutterstock This basic signaling pathway has been used repeatedly in development, after initially being discovered in Drosophila.

The Notch signaling pathway is involved in many aspects of tumor biology, from angiogenesis to cancer stem cell maintenance to tumor immunity. The role of Notch in the development and modulation of ...

The highly conserved Notch cell–cell signalling pathway operates in many different contexts across which the consequences can differ widely, despite the fact that the core pathway is very simple ...

The Notch signaling pathway, present in insects, worms and vertebrates, is involved in embryonic patterning as well as nervous system and cardiovascular development.