In a step toward smarter materials, researchers from Institute of Science Tokyo collaborated with researchers from Switzerland to develop a smart hinge-like molecule that can indicate mechanical ...

The protein-drug interaction was subjected to non-covalent interaction (NCI) analysis using the promolecular densities and reduced density gradients from the promolecular densities of the ...

Non-covalent interactions are fundamental for understanding the chemical behavior of porous materials with guest molecules, which is key for designing new materials. The Quantum Theory of Atoms in ...

We find that covalent attachment of EPI-002 and EPI-7170 increases the population of collapsed helical transactivation domain conformations relative to the populations observed in non-covalent binding ...

Phase 2 study of DZD8586, a non-covalent BBB penetrant LYN/BTK dual inhibitor, as monotherapy in relapsed/refractory diffuse large B-cell lymphoma (r/r DLBCL; TAI-SHAN9).

Non-muscle invasive bladder cancer burden: The impact of BCG shortage and its interaction with epidemiological patient profile—A population cohort study in Brazil.. If you have the appropriate ...

During a live event, Shuo Ma, MD, PhD, discussed the resistance mutation analysis of patients who had disease progression after receiving pirtobrutinib for BTK inhibitor–pretreated chronic lymphocytic ...

The company will present new findings comparing covalent versus non-covalent WRN inhibition mechanisms and demonstrating NDI-219216's superior efficacy across multiple preclinical MSI-H tumor models ...

The poster entitled "NDI-219216: a non-covalent, potent, selective and highly efficacious WRN inhibitor with best-in-class potential for the treatment of MSI-H tumors" highlights key preclinical ...

Non–vitamin K oral anticoagulants prevent stroke and systemic embolism in patients with nonvalvular atrial fibrillation. However, potential drug interactions with concomitant medications may ...

These intermolecular interactions are evidenced by the long extension of the wires and lateral growth by multicolumn wire formation. The combination and prevalence of such non-covalent interactions ...