The Burnham team, led by Dorit Hanein, Ph.D., was the first to reveal the 3D representation of myosin V "walking" along actin filament, a key protein involved in motility and muscle contraction.

Conformational changes within myosin lead to its movement relative to an actin filament. Several crystal structures exist for myosin bound to various nucleotides, but none with bound actin.

Myosin V has two "legs" connected to a "body," but exactly how the protein molecule moves its load along helical fibers of actin has been a mystery. "Studies have suggested two main models for ...

While their functions are diverse, myosins are similar in structure. NMII is so much like cardiac myosin, which keeps the ...

Models of how myosin, actin and the elastic scaffold protein titin work together have largely ignored the possibility that myosin filaments penetrate the Z-disc structure.

As expected, PP1c was translocated to the cell membrane upon blue light illumination being exposed upon the OptoMYPT expressing cells, and consequently, actin and myosin-mediated contractile force ...

Over the last several years the identification and functional characterization of the motor proteins actin and myosin in the nucleus has initiated a change in the view of nuclear processes. It is now ...

The biochemical assays were made using bovine cardiac myosin S1 and rabbit skeletal F-actin. These test compounds were mixed separately with an enzyme mixture of lactate dehydrogenase, bovine ...

With intensifying global warming and climate change, drought has become a major threat to global agriculture, impacting crop ...

The experimental image shows two proteins -- myosin (cyan) and actin (red) -- in a chick embryo during gastrulation, highlighting the main body axes and the dominant force-generating regions (cyan).